Personalized 3D-Printed CPAP Masks Improve CPAP Effectiveness in Children with OSA and Craniofacial Anomalies. RJ Morrison, KK VanKoevering, HB Nasser, KN Kashlan, SK Kline, DR Jensen, SP Edwards, F Hassan, HM Schotland, RD Chervin, SR Buchman, SJ Hollister, SL Garetz, GE Green.

Date: April 2015.
Source: COSM, Combined Otolaryngology Spring Meetings, on April 22-26, 2015 in Boston, MA USA.
Abstract: The high prevalence of obstructive sleep apnea (OSA) in children with craniofacial anomalies has been well-described. Failure of continuous positive airway pressure (CPAP) therapy may require potentially morbid surgery. Yet, achieving a functional mask-face interface using conventional masks is difficult due to leak and discomfort resulting from atypical faces. The objective was to develop a personalized CPAP mask using patient-specific computer-aided design (CAD) and three-dimensional (3D) printing for children with OSA and craniofacial anomalies which prevent effective CPAP therapy. University of Michigan Institutional Review Board approval was granted prior to initiating the study. A 3D model of a personalized CPAP mask based on the patient’s anatomy was designed using 3D photography (3dMD, Atlanta, GA) and CAD software (Materialise, Leuven, Belgium). The model is converted into a mold which is 3D printed (Stratasys, Rehovot, Israel) then filled with medical grade silicone to create the final mask. Validated OSA questionnaires (the OSA-18 and PSQ sleep disordered breathing subscale) and CPAP machine downloads were collected from the subject’s family at enrollment, after 1 month of consistent use of the mask, and at termination of use. Three patients have been enrolled to date. Results obtained to date are promising. Median leak improved by 74%, nightly compliance improved by 5.5%, and residual apnea-hypopnea index improved by 24%. Personalized CPAP masks can be successfully created utilizing 3D photography, patient-specific CAD, and 3D printing for children with craniofacial syndromes and OSA suffering from ineffective CPAP therapy. Results indicate this design and manufacturing process may improve CPAP therapy effectiveness in this patient population.

Poster: Personalized 3D-Printed CPAP Masks Improve CPAP Effectiveness in Children with OSA and Craniofacial Anomalies.
Authors: Robert J Morrison, Kyle K VanKoevering, Hassan B Nasser, Khaled N Kashlan, Stephanie K Kline, Daniel R Jensen, Sean P Edwards, Fauziya Hassan, Helena M Schotland, Ronald D Chervin, Steven R Buchman, Scott J Hollister, Susan L Garetz, Glenn E Green. University Of Michigan, Ann Arbor, MI, USA; Children’s Mercy Hospital, University Of Missouri Kansas City, Kansas City, MO, USA.

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