3D Imaging and Informatics Approaches to Diagnose Genetic Conditions. Curtis Deutsch, Ph.D.

Author: Curtis Deutsch, Ph.D., Director, Psychobiology Program, Eunice Kennedy Shriver Center, University of Massachusetts Medical School

Source: Bio-IT World Conference & Expo ‘13; Boston, Massachusetts

April, 2013

“With the support of NIH, we have developed the first quantitative normative database to diagnose craniofacial abnormalities. This new informatics resource, combined with novel methods in 3D surface imaging and 3D morphometry, provides the means of defining features of medical genetic conditions. These techniques permit, for the first time, objective and reliable quantitative diagnosis on a graded continuum.”

3dMDface System

The 3dMDface System was delivered to its first customer in 1999 and even though it is now on its third generation, many of the original first generation systems remain in daily use at customer sites around the world. We are happy to say that these systems are still actively supporting long term research initiatives and routinely providing 3D images of the patient’s reaction to treatment allowing the treating physician to monitor progress. Tens of thousands of people have been documented with the 3dMDface System throughout their treatment cycle and/or at various stages of growth. In medical as well as the dental worlds, the 3dMDface System is now considered the standard reference system for 3D anthropometric analysis. To date, it has been featured in scores of scientific publications and conference presentations around the world.

The current 3dMDface System is designed to be compact and very robust. Many of these systems are regularly transported as standard airline luggage to remote locations and treatment facilities around the world. This robustness easily translates to looking at home in the practice and/or clinic. Its simple but practical design allows to it to tuck away quite easily on the wall to minimize space.

3dMD has combined quality software engineering with state-of-the-art, industrial-grade hardware components, which are constructed to rigorous quality inspection and performance testing standards, to ensure image quality and consistency over time in high-throughput environments. With more than 1,200-plus camera units supplied around the world, the 3dMDface System is exceptionally reliable. In the rare event of an operational issue, our technicians can diagnose remotely and the situation can be rectified within hours. The 3dMDface system comes with a very simple user calibration routine allowing the camera alignment to be confirmed in a couple of minutes. Even after traveling thousands of miles, the 3dMDface System is effective in compensating for any type component movement. The system is supplied with very powerful but easy to use application software facilitating the storage, analysis and comparison of images. The system is designed for ease of upgradability and further modular units can be added as field modification.

Benefits:

  • Uses a non-invasive imaging technique for high-precision anatomical documentation
  • Supports surgical and treatment planning
  • Supports the monitoring and refinement of a patient’s reaction to treatment and/or therapeutic devices
  • Provides an objective foundation for quantifying patient outcomes
  • Facilitates more effective patient and colleague communications
  • Provides an alternative to correct facial surface information on 3D radiographs

A natural companion to CT/CBCT initiatives, 3dMD images register 1:1 to address CBCT surface artifacts caused by patient movement during the duration of the scan; allow compensation for soft tissue compression from CBCT stabilization aids (i.e. chin cup); eliminate the effect of soft tissue draping from supine devices; and supplement any missing anatomical data (i.e. nose). More importantly, 3dMD enables you to accurately document the patient’s natural head position and multiple facial expressions noninvasively throughout the treatment cycle.

Specifications:

  • Coverage: 180-degree face capture (ear-to-ear)
  • Capture speed: ~1.5 milliseconds at highest resolution…ideal for children
  • Geometry Generation: One continuous point cloud produced from the two stereo camera viewpoints, which eliminates the data errors associated with merging / stitching data sets together
  • Geometry Accuracy:
  • Range of color texture resolutions
  • Small footprint and wall-mount option
  • PC and laptop configurations available
  • Easy and economical upgrade path to the 3dMDcranial™ System

3dMDtrio System

3dMDtrio
The multi-purpose 3dMDtrio System non-invasively captures high-precision 3D facial and torso images in a compact footprint for use in a clinic or private practice. Engineered with medical-grade machine vision cameras, all 3dMD systems are designed for a long-life, generating repeatable, quality-oriented results 24/7 in high-throughput environments.

For example, the 3dMDtrio System was placed in The Science Museum, London by clinical teams from Great Ormond Street Hospital, University College Hospital, and Eastman Dental Hospital with the goal of building the world’s largest database of 3D facial images for research into face shape patterns. In this public forum, the 3dMDtrio easily achieved throughputs of 350 or more children per day with informed consent.

In contrast to systems architected on inexpensive SLR cameras, 3dMD systems capture the entire anatomical surface in ~1.5 milliseconds to eliminate motion and correction artifacts unavoidably generated with the inaccuracy of SLR cameras, which is the technology’s fundamental inability to tightly synchronize. Once you position your patient in front of the 3dMDtrio System, all necessary information is captured in one easy click, enabling your patients to maintain a sense of modesty during the quick documentation process.

While designed for supporting face procedures and breast augmentation, the 3dMDtrio System can be easily upgraded to the 3dMDquattro configuration to support an even wider variety of anatomic capture options such as breast reduction or body contouring.

  • Capture Speed: ~1.5 milliseconds
  • Subject capture: 200-degree full face and torso
  • Configuration: Three modular units of industrial machine vision cameras
  • Geometry Accuracy: <0.2mm RMS or better depending on mode

3dMDcranial System

The 3dMDcranial System was delivered to its first customer in 2001. In 2004, the 3dMDcranial System was re-engineered to take full advantage of 3dMD’s latest generation technology which was designed for very efficient work flow taking a more modular approach to patient imaging. Today, 3dMDcranial Systems are in daily use in institutions around the world to accurately document the size and shape of the patient’s craniofacial complex and cranial geometry. With an ultra-fast capture speed many of the systems are focused on scanning babies (3 months-plus) for orthotic size and fit applications to assist with assessing conditions such as positional plagiocephaly and craniosynostosis.

Depending on the user’s requirements such as coverage, portability, etc, the 3dMDcranial System can be organized into a number of different standard configurations or custom built for a designated room or area. The two standard systems available are the 3dMDcranial4 System and 3dMDcranial5 System. While both systems generate a 360-degree image of the subject’s head, the 3dMDcranial5 System is designed for very high throughput applications where there is less time for subject positioning and the 3dMDcranial4 System is designed to provide experienced users with more configuration flexibility.

Many 3dMD customers have taken advantage of our economical upgrade path when they wanted to move from solely imaging the face to include the full head. Since 3dMD systems are fully modular, upgrades can be purchased as an onsite upgrade from the 3dMDface System. With the 3dMDflex pack, the system can be re-configured as a 3dMDcranial System, a 3dMDtorso System or a customized configuration in a few minutes. The 3dMDcranial System comes with a very simple user calibration system allowing camera alignment to be confirmed in a couple of minutes. Even after long distance transportation, the 3dMD system is effective for compensating for any type component movement.

Customers who use the 3dMDcranial System in their patient protocols, routinely scanning both infant and adult heads, include Children’s Hospital, Seattle; Royal Children’s Hospital, Melbourne; University of Copenhagen; Osaka University; Children’s Hospital Los Angeles; and locations in Germany.

Specifications:

  • Coverage: Full 360-degree capture of the head
  • Capture speed: ~1.5 milliseconds at highest resolution, which eliminates the challenges and data errors associated with patient movement
  • Geometry Accuracy:
  • Lighting requirements: operates in standard clinic/office lighting conditions
  • Provision of data required to support for a range of custom orthotic manufacturing processes

3dMDtorso System

The 3dMDtorso System was delivered to its first customer in 2001. With the valuable input of a number of 3dMD customers, the 3dMDtorso System was re-engineered in 2006 to take a more flexible approach to patient imaging providing the clinic or research institution with a variety of shape capture options to ensure optimum surface area coverage whether the clinician is assessing requires a breast augmentation, lift, reduction, or reconstruction procedure. Today, 3dMDtorso Systems are in daily use in institutions and practices around the world.

3dMD’s aim has been to preserve the unparalleled subject coverage and proven simplicity of patient positioning and deliver a much more flexible configuration that is easy to use on even the most challenging of cases. As the 3dMDtorso System is designed to be modular, you have the system configuration options of a two viewpoint system in which coverage area is optimized for augmentation patients, a three viewpoint system, or a four viewpoint system which is optimized for all sizes in support of breast reduction patients. Regardless of system configuration, all machine vision cameras are tightly synchronized to capture the entire surface in only 1.5 milliseconds to eliminate any motion artifacts.

Once you position your patient in front of the system, all images are captured in one click, enabling your patients to maintain a sense of modesty during the process. You can capture the 3dMD image at the beginning of the patient consultation, process it immediately, and then sit down with your patient and her digital 3D image to start discussing next steps. Not only can you take before and after images to quantify and compare the results, you have the ability for very complex cases to take a series of images throughout treatment to help evaluate whether there is a need for further surgical intervention or treatment modification.

Specifications:

  • Coverage: 180-degree torso capture including under the breast
  • Capture speed: ~1.5 milliseconds at highest resolution
  • Geometry Generation: Depending on requirements, two, three, or four modular units of 6, 9, or 12 machine vision cameras and an industrial-grade flash system synchronized in a single capture

3dMDbody System

In 2001, 3dMD demonstrated its first full body scanner at SIGGRAPH, which is the premier annual conference on leading-edge theory and practice of computer graphics and interactive techniques. While our first production 3dMDbody System using our modular approach was delivered to a customer in 2007, 3dMDflex Systems capturing 360-degree body segments have continued to be delivered the past six years.

3dMDbody SystemThe 3dMDbody System is a highly flexible configuration that allows for a large number of variations in camera positioning and lenses. A customer can purchase our standard fixed model for the practice or clinic, or the 3dMDbody FLEX8 System, which enables the user to configure and reconfigure the modular units to fulfill a number of different capture tasks and coverage variations with a simple calibration process. The image capture time remains 1.5 milliseconds in line with 3dMD’s simpler face system, yet the 3dMD image generated retains equivalent anatomic accuracy and high resolution texture maps. In certain configurations more than one million polygons are automatically generated raw from the machine. Moreover, with the FLEX package, the 3dMDbody System can be reconfigured as one or more capture devices such as two 3dMDcranial4 systems, multiple 3dMDface Systems, or a 3dMDtorso4 System and a 3dMDcranial4 System. Your options are numerous!

Specifications:

  • Coverage: 360-degree capture of body from head to toe
  • Capture speed: ~1.5 milliseconds at highest resolution
  • Geometry Generation: One continuous point cloud produced from the four or eight stereo camera viewpoints, which eliminates the data errors associated with merging / stitching data sets together
  • Option for simultaneous acquisition of geometry and high resolution texture, or geometry only
  • Lighting requirements: operates in standard clinic/office lighting conditions

3dMDflex System

A cornerstone of 3dMD’s product architecture is the efficient use of standard building blocks or modular units. All 3dMD imaging systems take full advantage of this architecture to permit significant efficiencies through component interchangeability. The modular units, which from a hardware perspective consist of industrial grade machine vision cameras, are simple and elegant and work in conjunction with a range of optimal frameworks and structural mounting systems for easy installation, maintenance, and upgradeability.

Another major advantage of the 3dMDflex architecture is that a large number of specialist configurations can be more easily produced. Often these will permit full reconfiguration in matter of minutes. When combined with 3dMD’s easy field-user calibration process, 3dMD systems can be deployed for a very wide variety of applications.

If you would like to purchase a 3dMD system that you can configure as a 3dMDcranial System one day, a 3dMdtorso System the next, and then maybe two 3dMDface Systems in the field for population sample collecting, 3dMDflex packages give you this flexibility at an economical price. Currently on top of any standard system, 3dMD offers Flex3, Flex4, Flex5 and Flex8 kits which are bundled with full training and a range of options including lens packs and supporting tripods.

At 3dMD, we ARE high-precision 3D surface imaging and application for living, breathing human subjects. With a proven track record of more than 1,200 3D cameras globally, 3dMD is 100-percent focused on a customer community that requires superior data integrity for their
3D applications in medical, dental, biometrics, engineering, and research.

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